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OCR: function, In a subject with intact pituitary-adrena , a fall in following administration of metyrapone uent fall incortisol production is seen, with a subse ses a plasma cortisol levels (Fig. 7.16). This cat gas the compensatory release of ACTH for as lo he adrenal drug is administered. ACTH, acting on t cortex, accelerates the early stages of ster production biosynthesis and therefore increases the blocked by of all of the steroids up to the step that i of metyrapone. The increased production in the 11-deoxycortisol can be measured directl blood, where it appears as a 17-hydroxy-corticosteroid. A patient with fficiency hypothalamic, pituitary, or adrenal insu will show a diminished or absent respor See also: erapy . Cushing's Syndrome - Metyrapone Th est · Differential Diagnosis - Metyrap ...